Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.

Muschamp, John W; Hollander, Jonathan A; Thompson, Jennifer L; Voren, George; Hassinger, Linda C; Onvani, Sara; Kamenecka, Theodore M; Borgland, Stephanie L; Kenny, Paul J; Carlezon, William A

Muschamp, John W; Hollander, Jonathan A; Thompson, Jennifer L; Voren, George; Hassinger, Linda C; Onvani, Sara; Kamenecka, Theodore M; Borgland, Stephanie L; Kenny, Paul J; Carlezon, William A.

Affiliation

Muschamp JW; Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478.

Proc Natl Acad Sci U S A ; 111(16): E1648-55, 2014 Apr 22.

Article in En | MEDLINE | ID: mdl-24706819

Subject(s)

Dynorphins/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Neuropeptides/metabolism; Neurotransmitter Agents/metabolism; Reward; Ventral Tegmental Area/metabolism; Animals; Cocaine/administration & dosage; Cocaine/pharmacology; Dopaminergic Neurons/drug effects; Dopaminergic Neurons/metabolism; Dynorphins/antagonists & inhibitors; Hypothalamus/drug effects; Hypothalamus/metabolism; Impulsive Behavior/metabolism; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides/antagonists & inhibitors; Orexin Receptors/metabolism; Orexins; Self Administration; Synaptic Transmission/drug effects; Ventral Tegmental Area/drug effects

Key words

addiction; kappa-opioid receptor; mood; neurotransmission; stress

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Full text: 1 Database: MEDLINE Main subject: Reward / Neuropeptides / Dynorphins / Ventral Tegmental Area / Neurotransmitter Agents / Intracellular Signaling Peptides and Proteins Type of study: Prognostic_studies Limits: Animals Language: En Year: 2014 Type: Article

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