Molecular basis of the general base catalysis of an &#945;/ß-hydrolase catalytic triad.

Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong

Molecular basis of the general base catalysis of an α/ß-hydrolase catalytic triad.

Sun, Yueru; Yin, Shuhui; Feng, Yitao; Li, Jie; Zhou, Jiahai; Liu, Changdong; Zhu, Guang; Guo, Zhihong.

Affiliation

Sun Y; From the Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and.
Yin S; From the Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and.
Feng Y; From the Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and.
Li J; State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Zhou J; State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Liu C; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and Division of Life Sciences, and.
Zhu G; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and Division of Life Sciences, and.
Guo Z; From the Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region (SAR), China and chguo@ust.hk.

J Biol Chem ; 289(22): 15867-79, 2014 May 30.

Article in En | MEDLINE | ID: mdl-24737327

Subject(s)

Escherichia coli/enzymology; Oxo-Acid-Lyases/chemistry; Oxo-Acid-Lyases/metabolism; Aspartic Acid/metabolism; Catalysis; Crystallography, X-Ray; Enzyme Activation/physiology; Histidine/metabolism; Hydrogen Bonding; Mutagenesis, Site-Directed; Oxo-Acid-Lyases/genetics; Protein Structure, Secondary; Protein Structure, Tertiary; Serine/metabolism; Structure-Activity Relationship; Vitamin K/biosynthesis

Key words

Crystal Structure; Enzyme Mechanisms; Hydrolases; Open-Closed Conformational Change; Protein Conformation; Vitamin K

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