LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Schorch, Björn; Song, Shuo; van Diemen, Ferdy R; Bock, Hans H; May, Petra; Herz, Joachim; Brummelkamp, Thijn R; Papatheodorou, Panagiotis; Aktories, Klaus

Schorch, Björn; Song, Shuo; van Diemen, Ferdy R; Bock, Hans H; May, Petra; Herz, Joachim; Brummelkamp, Thijn R; Papatheodorou, Panagiotis; Aktories, Klaus.

Affiliation

Schorch B; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

Proc Natl Acad Sci U S A ; 111(17): 6431-6, 2014 Apr 29.

Article in En | MEDLINE | ID: mdl-24737893

Subject(s)

Bacterial Toxins/metabolism; Clostridium perfringens/metabolism; Low Density Lipoprotein Receptor-Related Protein-1/metabolism; Animals; Bacterial Toxins/chemistry; Cell Membrane/metabolism; Embryo, Mammalian/cytology; Endocytosis; Fibroblasts/metabolism; Genetic Testing; Glycosylation; Haploidy; HeLa Cells; Humans; Mice; Models, Biological; Protein Binding; Protein Structure, Tertiary

Key words

receptor-mediated endocytosis; toxin receptor

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Full text: 1 Database: MEDLINE Main subject: Bacterial Toxins / Clostridium perfringens / Low Density Lipoprotein Receptor-Related Protein-1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2014 Type: Article

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