Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats.

Kim, Yoon; Kim, Unyong; Kim, In Sook; Lee, Sung-Hack; Lee, Jaeick; Kim, Dong-Hyun; Yoo, Hye Hyun

Kim, Yoon; Kim, Unyong; Kim, In Sook; Lee, Sung-Hack; Lee, Jaeick; Kim, Dong-Hyun; Yoo, Hye Hyun.

Affiliation

Kim Y; Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University , Ansan , Republic of Korea .

Xenobiotica ; 44(7): 627-34, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24738939

Subject(s)

Dipeptidyl-Peptidase IV Inhibitors/pharmacokinetics; Piperidones/pharmacokinetics; Pyrimidines/pharmacokinetics; Administration, Oral; Animals; Bile/metabolism; Carbon Radioisotopes/pharmacokinetics; Dipeptidyl-Peptidase IV Inhibitors/administration & dosage; Dipeptidyl-Peptidase IV Inhibitors/urine; Feces; Hydroxylation; Inactivation, Metabolic; Intestinal Absorption; Male; Piperidones/administration & dosage; Piperidones/urine; Pyrimidines/administration & dosage; Pyrimidines/urine; Rats, Sprague-Dawley; Tissue Distribution

Key words

Absorption; distribution; excretion; gemigliptin; metabolism

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Full text: 1 Database: MEDLINE Main subject: Piperidones / Pyrimidines / Dipeptidyl-Peptidase IV Inhibitors Limits: Animals Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Piperidones / Pyrimidines / Dipeptidyl-Peptidase IV Inhibitors Limits: Animals Language: En Year: 2014 Type: Article