The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.
FEBS Lett
; 588(10): 1899-905, 2014 May 21.
Article
in En
| MEDLINE
| ID: mdl-24768994
ABSTRACT
Human Hikeshi (HsHikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe (SpHikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, SpHikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, SpHikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of SpHikeshi/Opi10 are discussed and compared to the functions of HsHikeshi.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Schizosaccharomyces
/
Carrier Proteins
/
Heat-Shock Response
/
Schizosaccharomyces pombe Proteins
Limits:
Humans
Language:
En
Year:
2014
Type:
Article