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Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.
Huber-Lang, Markus; Barratt-Due, Andreas; Pischke, Søren E; Sandanger, Øystein; Nilsson, Per H; Nunn, Miles A; Denk, Stephanie; Gaus, Wilhelm; Espevik, Terje; Mollnes, Tom E.
Affiliation
  • Huber-Lang M; Department of Traumatology, Center of Surgery, University of Ulm, Ulm 89081, Germany;
  • Barratt-Due A; Department of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo N-0027, Norway; K.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo N-0027, Norway;
  • Pischke SE; The Interventional Centre, Oslo University Hospital, Oslo N-0027, Norway; Department of Anesthesiology, Oslo University Hospital, Oslo N-0027, Norway;
  • Sandanger Ø; Research Institute of Internal Medicine, Oslo University Hospital, Oslo N-0027, Norway;
  • Nilsson PH; Department of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo N-0027, Norway;
  • Nunn MA; Centre for Ecology and Hydrology, Wallingford, Oxfordshire OX10 8BB, United Kingdom;
  • Denk S; Department of Traumatology, Center of Surgery, University of Ulm, Ulm 89081, Germany;
  • Gaus W; Department of Epidemiology and Biostatistics, University of Ulm, Ulm 89081, Germany;
  • Espevik T; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim 7491, Norway;
  • Mollnes TE; Department of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo N-0027, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim 7491, Norway; Research Laboratory, Nordland Hospital Bodø, University of Tromsø, Tromsø 90
J Immunol ; 192(11): 5324-31, 2014 Jun 01.
Article in En | MEDLINE | ID: mdl-24790148
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Full text: 1 Database: MEDLINE Main subject: Complement C5 / Cytokines / Sepsis / Lipopolysaccharide Receptors / Antibodies, Neutralizing Limits: Animals Language: En Year: 2014 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Complement C5 / Cytokines / Sepsis / Lipopolysaccharide Receptors / Antibodies, Neutralizing Limits: Animals Language: En Year: 2014 Type: Article