RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells.
Gene
; 545(1): 111-6, 2014 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-24792891
ABSTRACT
The RUNX1/AML1 gene is among the most frequently mutated genes in human leukaemia. However, its association with T-cell acute lymphoblastic leukaemia (T-ALL) remains poorly understood. In order to examine RUNX1 point mutations in T-ALL, we conducted an amplicon-based deep sequencing in 65 Southeast Asian childhood patients and 20 T-ALL cell lines, and detected RUNX1 mutations in 6 patients (9.2%) and 5 cell lines (25%). Interestingly, RUNX1-mutated T-ALL cases seem to constitute a subset of early immature T-ALL that may originate from differentiated T-cells. This result provides a deeper insight into the mechanistic basis for leukaemogenesis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Point Mutation
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Core Binding Factor Alpha 2 Subunit
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
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Child
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Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Year:
2014
Type:
Article