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Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.
Wijnker, Paul J M; Sequeira, Vasco; Witjas-Paalberends, E Rosalie; Foster, D Brian; dos Remedios, Cristobal G; Murphy, Anne M; Stienen, Ger J M; van der Velden, Jolanda.
Affiliation
  • Wijnker PJ; Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: p.wij
  • Sequeira V; Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: v.sequeiraoliveira@vumc.nl.
  • Witjas-Paalberends ER; Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.paalberends@vumc.nl.
  • Foster DB; Department of Pediatrics/Division of Cardiology, Johns Hopkins University School of Medicine, Ross Bldg 1144/720 Rutland Avenue, Baltimore, MD 21205, USA. Electronic address: dbrianfoster@jhmi.edu.
  • dos Remedios CG; Muscle Research Unit, Bosch Institute, The University of Sydney, Sydney, Australia. Electronic address: cris.dosremedios@sydney.edu.au.
  • Murphy AM; Department of Pediatrics/Division of Cardiology, Johns Hopkins University School of Medicine, Ross Bldg 1144/720 Rutland Avenue, Baltimore, MD 21205, USA. Electronic address: murphy@jhmi.edu.
  • Stienen GJ; Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands. Electronic address: g.stienen@vumc.nl.
  • van der Velden J; Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands. Electronic address: j.vandervelden@vumc.nl.
Arch Biochem Biophys ; 554: 11-21, 2014 Jul 15.
Article in En | MEDLINE | ID: mdl-24814372
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase C / Cyclic AMP-Dependent Protein Kinases / Troponin I / Myocytes, Cardiac Type of study: Diagnostic_studies Limits: Female / Humans / Male / Middle aged Language: En Year: 2014 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase C / Cyclic AMP-Dependent Protein Kinases / Troponin I / Myocytes, Cardiac Type of study: Diagnostic_studies Limits: Female / Humans / Male / Middle aged Language: En Year: 2014 Type: Article