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Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.
Sugeno, Naoto; Hasegawa, Takafumi; Tanaka, Nobuyuki; Fukuda, Mitsunori; Wakabayashi, Koichi; Oshima, Ryuji; Konno, Masashi; Miura, Emiko; Kikuchi, Akio; Baba, Toru; Anan, Tadashi; Nakao, Mitsuyoshi; Geisler, Sven; Aoki, Masashi; Takeda, Atsushi.
Affiliation
  • Sugeno N; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Hasegawa T; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan, thasegawa@med.tohoku.ac.jp.
  • Tanaka N; the Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori 981-1293, Japan.
  • Fukuda M; the Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Wakabayashi K; the Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.
  • Oshima R; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan, the Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori 981-1293, Japan.
  • Konno M; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Miura E; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Kikuchi A; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Baba T; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Anan T; the Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan.
  • Nakao M; the Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan, and.
  • Geisler S; the Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, German Centre for Neurodegenerative Diseases, Tübingen 72076, Germany.
  • Aoki M; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
  • Takeda A; From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
J Biol Chem ; 289(26): 18137-51, 2014 Jun 27.
Article in En | MEDLINE | ID: mdl-24831002
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Full text: 1 Database: MEDLINE Main subject: Endosomes / Ubiquitin-Protein Ligases / Alpha-Synuclein / Endosomal Sorting Complexes Required for Transport / Lysine Limits: Humans Language: En Year: 2014 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Endosomes / Ubiquitin-Protein Ligases / Alpha-Synuclein / Endosomal Sorting Complexes Required for Transport / Lysine Limits: Humans Language: En Year: 2014 Type: Article