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Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.
Hong, Yong Rae; Kim, Hyun Tae; Ro, Seonggu; Cho, Joong Myung; Lee, Sang Hwi; Kim, In Su; Jung, Young Hoon.
Affiliation
  • Hong YR; CrystalGenomics, Inc., 5F, Tower A, Korea Bio Park 694-1, Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Republic of Korea; School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • Kim HT; CrystalGenomics, Inc., 5F, Tower A, Korea Bio Park 694-1, Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Republic of Korea.
  • Ro S; CrystalGenomics, Inc., 5F, Tower A, Korea Bio Park 694-1, Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Republic of Korea. Electronic address: sgro@cgxinc.com.
  • Cho JM; CrystalGenomics, Inc., 5F, Tower A, Korea Bio Park 694-1, Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Republic of Korea.
  • Lee SH; School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • Kim IS; School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • Jung YH; School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Electronic address: yhjung@skku.edu.
Bioorg Med Chem Lett ; 24(14): 3142-5, 2014 Jul 15.
Article in En | MEDLINE | ID: mdl-24894560
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Thiazoles / Enzyme Inhibitors / Drug Discovery / Hypoxia-Inducible Factor-Proline Dioxygenases / Acetamides Type of study: Prognostic_studies Limits: Humans Language: En Year: 2014 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Thiazoles / Enzyme Inhibitors / Drug Discovery / Hypoxia-Inducible Factor-Proline Dioxygenases / Acetamides Type of study: Prognostic_studies Limits: Humans Language: En Year: 2014 Type: Article