Human cellular differences in cAMP--CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder.

Gaspar, Ludmila; van de Werken, Maan; Johansson, Anne-Sophie; Moriggi, Ermanno; Owe-Larsson, Björn; Kocks, Janwillem W H; Lundkvist, Gabriella B; Gordijn, Marijke C M; Brown, Steven A

Gaspar, Ludmila; van de Werken, Maan; Johansson, Anne-Sophie; Moriggi, Ermanno; Owe-Larsson, Björn; Kocks, Janwillem W H; Lundkvist, Gabriella B; Gordijn, Marijke C M; Brown, Steven A.

Affiliation

Gaspar L; Institute of Pharmacology and Toxicology, University of Zurich, 190 Winterthurerstrasse, Zurich, Switzerland.

Eur J Neurosci ; 40(1): 2206-15, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24898566

Subject(s)

Bipolar Disorder/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Cyclic AMP/metabolism; Light; Melatonin/metabolism; Adult; Cells, Cultured; Cohort Studies; Female; Fibroblasts/metabolism; Genetic Vectors; Humans; Lentivirus/genetics; Male; Middle Aged; Photic Stimulation; Signal Transduction; White People; Young Adult

Key words

bipolar disorder; cAMP-CREB; circadian; fibroblast; inter-individual differences; melatonin

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Full text: 1 Database: MEDLINE Main subject: Bipolar Disorder / Cyclic AMP Response Element-Binding Protein / Cyclic AMP / Light / Melatonin Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2014 Type: Article

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