Purinergic signaling mediated by P2X7 receptors controls myelination in sciatic nerves.

Faroni, A; Smith, R J P; Procacci, P; Castelnovo, L F; Puccianti, E; Reid, A J; Magnaghi, V; Verkhratsky, A

Faroni, A; Smith, R J P; Procacci, P; Castelnovo, L F; Puccianti, E; Reid, A J; Magnaghi, V; Verkhratsky, A.

Affiliation

Faroni A; Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

J Neurosci Res ; 92(10): 1259-69, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24903685

Subject(s)

Gene Expression Regulation/genetics; Myelin Sheath/metabolism; Receptors, Purinergic P2X7/metabolism; Schwann Cells/metabolism; Sciatic Nerve/metabolism; Signal Transduction/physiology; Animals; Arabidopsis Proteins/metabolism; HEK293 Cells; Humans; Intramolecular Transferases/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Myelin Proteins/genetics; Myelin Proteins/metabolism; Myelin Sheath/ultrastructure; Receptors, Purinergic P2X7/genetics; Schwann Cells/ultrastructure; Sciatic Nerve/cytology; Transfection

Key words

ATP; P2X; Schwann cells; cell fate; myelin; sciatic nerve

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Full text: 1 Database: MEDLINE Main subject: Schwann Cells / Sciatic Nerve / Signal Transduction / Gene Expression Regulation / Receptors, Purinergic P2X7 / Myelin Sheath Limits: Animals / Humans / Male Language: En Year: 2014 Type: Article

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