Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.

Kosaka, K; Imamura, M; Hayes, C N; Abe, H; Hiraga, N; Yoshimi, S; Murakami, E; Kawaoka, T; Tsuge, M; Aikata, H; Miki, D; Ochi, H; Matsui, H; Kanai, A; Inaba, T; Chayama, K

Kosaka, K; Imamura, M; Hayes, C N; Abe, H; Hiraga, N; Yoshimi, S; Murakami, E; Kawaoka, T; Tsuge, M; Aikata, H; Miki, D; Ochi, H; Matsui, H; Kanai, A; Inaba, T; Chayama, K.

Affiliation

Kosaka K; Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan.

J Viral Hepat ; 22(2): 158-65, 2015 Feb.

Article in En | MEDLINE | ID: mdl-24943406

Subject(s)

Antiviral Agents/therapeutic use; Drug Resistance, Viral; Hepacivirus/drug effects; Hepatitis C, Chronic/virology; High-Throughput Nucleotide Sequencing; Imidazoles/therapeutic use; Isoquinolines/therapeutic use; Sulfonamides/therapeutic use; Administration, Oral; Aged; Antiviral Agents/pharmacology; Carbamates; Drug Therapy, Combination/methods; Genotype; Hepacivirus/classification; Hepacivirus/genetics; Hepacivirus/isolation & purification; Hepatitis C, Chronic/drug therapy; Humans; Imidazoles/pharmacology; Isoquinolines/pharmacology; Middle Aged; Mutant Proteins/genetics; Mutation, Missense; Pyrrolidines; Sulfonamides/pharmacology; Time Factors; Valine/analogs & derivatives; Viral Nonstructural Proteins/genetics

Key words

antiviral resistance; asunaprevir; combination treatment; daclatasvir; deep sequencing

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Sulfonamides / Hepacivirus / Hepatitis C, Chronic / Drug Resistance, Viral / High-Throughput Nucleotide Sequencing / Imidazoles / Isoquinolines Type of study: Prognostic_studies Limits: Aged / Humans / Middle aged Language: En Year: 2015 Type: Article

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