Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis.
Int Immunol
; 26(10): 579-82, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-24981709
ABSTRACT
IFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4(+) T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN-γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ expression of T cells was observed. However, miR-29a was differentially expressed in T cells during chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for impaired IFN-γ expression.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
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T-Lymphocytes
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Gene Expression Regulation
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Interferon-gamma
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MicroRNAs
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Mycobacterium tuberculosis
Type of study:
Observational_studies
Limits:
Adult
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Female
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Humans
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Male
/
Middle aged
Language:
En
Year:
2014
Type:
Article