Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

Stothert, Andrew R; Suntharalingam, Amirthaa; Huard, Dustin J E; Fontaine, Sarah N; Crowley, Vincent M; Mishra, Sanket; Blagg, Brian S J; Lieberman, Raquel L; Dickey, Chad A

Stothert, Andrew R; Suntharalingam, Amirthaa; Huard, Dustin J E; Fontaine, Sarah N; Crowley, Vincent M; Mishra, Sanket; Blagg, Brian S J; Lieberman, Raquel L; Dickey, Chad A.

Affiliation

Stothert AR; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL 33613, USA.
Suntharalingam A; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL 33613, USA.
Huard DJ; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA and.
Fontaine SN; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL 33613, USA.
Crowley VM; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66049, USA.
Mishra S; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66049, USA.
Blagg BS; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66049, USA.
Lieberman RL; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA and.
Dickey CA; Department of Molecular Medicine and Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL 33613, USA, cdickey@health.usf.edu.

Hum Mol Genet ; 23(24): 6470-80, 2014 Dec 15.

Article in En | MEDLINE | ID: mdl-25027323

Subject(s)

Cytoskeletal Proteins/metabolism; Eye Proteins/metabolism; Glaucoma, Open-Angle/metabolism; Glycoproteins/metabolism; Imidazoles/pharmacology; Membrane Glycoproteins/antagonists & inhibitors; Cytoskeletal Proteins/genetics; Dose-Response Relationship, Drug; Eye Proteins/genetics; Gene Expression Regulation; Glaucoma, Open-Angle/drug therapy; Glaucoma, Open-Angle/genetics; Glaucoma, Open-Angle/pathology; Glycoproteins/genetics; HEK293 Cells; Humans; Imidazoles/chemical synthesis; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Molecular Docking Simulation; Protein Aggregates/drug effects; Protein Binding/drug effects; Protein Folding/drug effects; Protein Structure, Quaternary; Protein Structure, Tertiary; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Trabecular Meshwork

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Membrane Glycoproteins / Glycoproteins / Glaucoma, Open-Angle / Cytoskeletal Proteins / Eye Proteins / Imidazoles Limits: Humans Language: En Year: 2014 Type: Article

Fulltext

XML

PubMed Links

Search on Google