Luminescent cyclometalated platinum(II) complex forms emissive intercalating adducts with double-stranded DNA and RNA: differential emissions and anticancer activities.

Zou, Taotao; Liu, Jia; Lum, Ching Tung; Ma, Chensheng; Chan, Ruth Chau-Ting; Lok, Chun-Nam; Kwok, Wai-Ming; Che, Chi-Ming

Zou, Taotao; Liu, Jia; Lum, Ching Tung; Ma, Chensheng; Chan, Ruth Chau-Ting; Lok, Chun-Nam; Kwok, Wai-Ming; Che, Chi-Ming.

Affiliation

Zou T; State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Centre and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong (China).

Angew Chem Int Ed Engl ; 53(38): 10119-23, 2014 Sep 15.

Article in En | MEDLINE | ID: mdl-25044924

Subject(s)

Antineoplastic Agents/pharmacology; DNA/drug effects; Luminescence; Neoplasms, Experimental/drug therapy; Organoplatinum Compounds/pharmacology; RNA, Double-Stranded/drug effects; Animals; Antineoplastic Agents/chemistry; Cell Line, Tumor; Cell Proliferation/drug effects; DNA/chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental/pathology; Organoplatinum Compounds/chemistry; RNA, Double-Stranded/chemistry; Structure-Activity Relationship

Key words

DNA; anticancer; exciplex emission; platinum; topoisomeraseâI

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Full text: 1 Database: MEDLINE Main subject: Organoplatinum Compounds / DNA / RNA, Double-Stranded / Luminescence / Neoplasms, Experimental / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2014 Type: Article

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