Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.

Yasuda, Kei; Watkins, Amanda A; Kochar, Guneet S; Wilson, Gabriella E; Laskow, Bari; Richez, Christophe; Bonegio, Ramon G; Rifkin, Ian R

Yasuda, Kei; Watkins, Amanda A; Kochar, Guneet S; Wilson, Gabriella E; Laskow, Bari; Richez, Christophe; Bonegio, Ramon G; Rifkin, Ian R.

Affiliation

Yasuda K; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Watkins AA; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Kochar GS; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Wilson GE; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Laskow B; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Richez C; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Bonegio RG; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Rifkin IR; Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.

PLoS One ; 9(7): e103478, 2014.

Article in En | MEDLINE | ID: mdl-25076492

Subject(s)

GTPase-Activating Proteins/genetics; Interferon Regulatory Factors/genetics; Lupus Erythematosus, Systemic/pathology; Animals; Autoantibodies/blood; B-Cell Activating Factor/blood; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; Disease Models, Animal; GTPase-Activating Proteins/metabolism; Guanine Nucleotide Exchange Factors; Immunoglobulin Isotypes/metabolism; Interferon Regulatory Factors/deficiency; Interferon Regulatory Factors/metabolism; Kidney Diseases/metabolism; Kidney Diseases/pathology; Lupus Erythematosus, Systemic/metabolism; Lupus Erythematosus, Systemic/mortality; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Mutation; Severity of Illness Index; Spleen/cytology; Survival Analysis; Th1 Cells/metabolism

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Full text: 1 Database: MEDLINE Main subject: GTPase-Activating Proteins / Interferon Regulatory Factors / Lupus Erythematosus, Systemic Type of study: Prognostic_studies Limits: Animals Language: En Year: 2014 Type: Article

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