Your browser doesn't support javascript.
loading
Prevalence of human papillomavirus infection in oral squamous cell carcinoma: a case-control study in Wuhan, China.
Gan, Li-Li; Zhang, Hao; Guo, Ji-Hua; Fan, Ming-Wen.
Affiliation
  • Gan LL; Hubei-MOST KLOS and KLOBME, School and Hospital of Stomatology, Wuhan University, Wuhan, China E-mail : fmw@whuss.com.
Asian Pac J Cancer Prev ; 15(14): 5861-5, 2014.
Article in En | MEDLINE | ID: mdl-25081714
High risk forms of the human papilloma virus (HPV) are generally accepted as necessary causative agents for cervical cancer. Recently, a possible relation between HPV and oral squamous cell carcinoma (OSCC) has also been noticed. The present study was conducted to investigate the prevalence of HPV infection in OSCCs in Wuhan city. DNA samples were collected from fresh tissues in 200 patients with OSCC and 68 normal controls. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The prevalence of HPV of all types in the OSCC group was higher than in the control group (55/200 vs 2/68, OR=11.5, 95% CI=2.6-50.2). HPV16 and HPV18 were the main types detected, with HPV6 was the only low-risk type identified. High-risk HPV types HPV16 and HPV18 are prevalent in OSCC patients and may participate in the development of OSCC with traditional risk factors, tobacco and alcohol, possibly exerting synergistic effects. The results of multinomial logistic regression showed that those who smoked, consumed alcohol and with HPV infection have the highest risk of developing oral cancer (OR=13.3, 95% CI=3.1-56.8). Adjusted for age, smoking and alcohol use, HPV infection was independently associated with oral squamous cell carcinoma.
Subject(s)
Search on Google
Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Papillomavirus Infections Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Year: 2014 Type: Article
Search on Google
Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Papillomavirus Infections Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Year: 2014 Type: Article