Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas.

Cheng, Feng; Zhu, Leilei; Lue, Hongqi; Bernhagen, Jürgen; Schwaneberg, Ulrich

Cheng, Feng; Zhu, Leilei; Lue, Hongqi; Bernhagen, Jürgen; Schwaneberg, Ulrich.

Affiliation

Cheng F; Lehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074, Aachen, Germany.

Appl Microbiol Biotechnol ; 99(3): 1237-47, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25104032

Subject(s)

Antineoplastic Agents/metabolism; Arginine/metabolism; Directed Molecular Evolution/methods; Hydrolases/genetics; Hydrolases/metabolism; Pseudomonas/enzymology; Ammonia/analysis; Cell Line, Tumor; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Kinetics; Melanoma/drug therapy; Mutagenesis

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Full text: 1 Database: MEDLINE Main subject: Arginine / Pseudomonas / Directed Molecular Evolution / Hydrolases / Antineoplastic Agents Limits: Humans Language: En Year: 2015 Type: Article

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