Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

Sephton, Selena Milicevic; Herde, Adrienne Müller; Mu, Linjing; Keller, Claudia; Rüdisühli, Sonja; Auberson, Yves; Schibli, Roger; Krämer, Stefanie D; Ametamey, Simon M

Sephton, Selena Milicevic; Herde, Adrienne Müller; Mu, Linjing; Keller, Claudia; Rüdisühli, Sonja; Auberson, Yves; Schibli, Roger; Krämer, Stefanie D; Ametamey, Simon M.

Affiliation

Sephton SM; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

Eur J Nucl Med Mol Imaging ; 42(1): 128-37, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25139517

Subject(s)

Oximes/pharmacokinetics; Pyridines/pharmacokinetics; Radiopharmaceuticals/pharmacokinetics; Receptor, Metabotropic Glutamate 5/antagonists & inhibitors; Animals; Drug Evaluation, Preclinical; Male; Oximes/chemical synthesis; Positron-Emission Tomography; Pyridines/chemical synthesis; Radiopharmaceuticals/adverse effects; Radiopharmaceuticals/chemical synthesis; Rats; Rats, Wistar; Reproducibility of Results; Tissue Distribution

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Oximes / Pyridines / Radiopharmaceuticals / Receptor, Metabotropic Glutamate 5 Limits: Animals Language: En Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google