Targeting the actin cytoskeleton: selective antitumor action via trapping PKCÉ.

Foerster, F; Braig, S; Moser, C; Kubisch, R; Busse, J; Wagner, E; Schmoeckel, E; Mayr, D; Schmitt, S; Huettel, S; Zischka, H; Mueller, R; Vollmar, A M

Targeting the actin cytoskeleton: selective antitumor action via trapping PKCÉ.

Foerster, F; Braig, S; Moser, C; Kubisch, R; Busse, J; Wagner, E; Schmoeckel, E; Mayr, D; Schmitt, S; Huettel, S; Zischka, H; Mueller, R; Vollmar, A M.

Affiliation

Foerster F; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Braig S; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Moser C; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Kubisch R; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.
Busse J; Department of Pharmacy, Pharmaceutical Biotechnology, University of Munich, Munich, Germany.
Wagner E; Department of Pharmacy, Pharmaceutical Biotechnology, University of Munich, Munich, Germany.
Schmoeckel E; Institute of Pathology, University of Munich, Munich, Germany.
Mayr D; Institute of Pathology, University of Munich, Munich, Germany.
Schmitt S; Institute for Molecular Toxicology and Pharmacology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Huettel S; Institute of Pathology, University of Munich, Munich, Germany.
Zischka H; Institute for Molecular Toxicology and Pharmacology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Mueller R; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Vollmar AM; Department of Pharmacy, Pharmaceutical Biology, University of Munich, Munich, Germany.

Cell Death Dis ; 5: e1398, 2014 Aug 28.

Article in En | MEDLINE | ID: mdl-25165884

Subject(s)

Actin Cytoskeleton/metabolism; Actins/metabolism; Protein Kinase C/metabolism; Actin Cytoskeleton/drug effects; Actins/genetics; Animals; Antineoplastic Agents/therapeutic use; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Binding Sites; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Cytochromes c/metabolism; Depsipeptides/therapeutic use; Depsipeptides/toxicity; Female; Fluorescence Recovery After Photobleaching; Hexokinase/metabolism; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial/drug effects; Mice; Mice, SCID; Mitochondria/metabolism; Phosphatidylserines/pharmacology; Signal Transduction; Transplantation, Heterologous; Voltage-Dependent Anion Channels/metabolism; bcl-Associated Death Protein/metabolism

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Full text: 1 Database: MEDLINE Main subject: Actin Cytoskeleton / Protein Kinase C / Actins Limits: Animals / Female / Humans Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Actin Cytoskeleton / Protein Kinase C / Actins Limits: Animals / Female / Humans Language: En Year: 2014 Type: Article