Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange.

Sonar, Mahesh V; Wampole, Matthew E; Jin, Yuan-Yuan; Chen, Chang-Po; Thakur, Mathew L; Wickstrom, Eric

Sonar, Mahesh V; Wampole, Matthew E; Jin, Yuan-Yuan; Chen, Chang-Po; Thakur, Mathew L; Wickstrom, Eric.

Affiliation

Sonar MV; Biochemistry & Molecular Biology, §Radiology, and â¥Kimmel Cancer Center Thomas Jefferson University , Philadelphia, Pennsylvania 19107, United States.

Bioconjug Chem ; 25(9): 1697-708, 2014 Sep 17.

Article in En | MEDLINE | ID: mdl-25180641

Subject(s)

Benzothiazoles/chemistry; Lung Neoplasms/pathology; Peptide Nucleic Acids/chemistry; Proto-Oncogene Proteins/genetics; Quinolines/chemistry; ras Proteins/genetics; Cell Line, Tumor; Humans; Molecular Dynamics Simulation; Mutation; Nucleic Acid Conformation; Nucleic Acid Hybridization; Proto-Oncogene Proteins p21(ras); RNA, Messenger/chemistry; Spectrometry, Fluorescence; Temperature; Thermodynamics

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Full text: 1 Database: MEDLINE Main subject: Quinolines / Proto-Oncogene Proteins / Ras Proteins / Peptide Nucleic Acids / Benzothiazoles / Lung Neoplasms Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2014 Type: Article

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