ABSTRACT
INTRODUCTION:
Bisphosphonate (Bp)-
ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-
ibandronate may also interfere during
orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-
ibandronate on experimental
tooth movement in
rabbits. MATERIALS AND
METHODS:
Twenty
rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received
nickel-
titanium closed coil springs with 100
g force between mandibular
molar and
incisors. Group-1
animals received 1 ml
normal saline and Group-2
animals received
ibandronate solution (0.3 mg/kg
body weight) locally, mesial to the mandibular
molar on the 1(st), 7(th), and 14(th) day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1(st) and 21(st) day using a digital
X-ray unit (Siemens
X-ray systems, 300 mA Pleomophos analog, 2008,
Germany). Individually, each
animal's radiograph was traced manually and superimposed. The
molar tooth movement was measured with the help of a standard
metric scale.
RESULTS:
The
Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).
CONCLUSION:
The retarded
molar tooth movement was noticed in local
drug administered
rabbits, which could be beneficial in
orthodontics to control the undesired
tooth movement.
