Elongation factor-2 kinase regulates TG2/ß1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion.

Ashour, Ahmed A; Gurbuz, Nilgun; Alpay, Sultan Neslihan; Abdel-Aziz, Abdel-Aziz H; Mansour, Ahmed M; Huo, Longfei; Ozpolat, Bulent

Ashour, Ahmed A; Gurbuz, Nilgun; Alpay, Sultan Neslihan; Abdel-Aziz, Abdel-Aziz H; Mansour, Ahmed M; Huo, Longfei; Ozpolat, Bulent.

Affiliation

Ashour AA; Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

J Cell Mol Med ; 18(11): 2235-51, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25215932

Subject(s)

Elongation Factor 2 Kinase/genetics; Integrin beta1/biosynthesis; Pancreatic Neoplasms/genetics; Receptors, Urokinase Plasminogen Activator/biosynthesis; Transglutaminases/biosynthesis; Acetophenones/administration & dosage; Benzopyrans/administration & dosage; Cell Line, Tumor; Elongation Factor 2 Kinase/metabolism; Epithelial-Mesenchymal Transition/genetics; GTP-Binding Proteins; Gene Expression Regulation, Neoplastic/drug effects; Humans; Integrin beta1/genetics; Neoplasm Invasiveness/genetics; Pancreatic Neoplasms/pathology; Protein Glutamine gamma Glutamyltransferase 2; RNA, Small Interfering; Receptors, Urokinase Plasminogen Activator/genetics; Signal Transduction/genetics; src-Family Kinases/biosynthesis; src-Family Kinases/genetics; Pancreatic Neoplasms

Key words

Ca2+/calmodulin-dependent kinase III; EMT; MMP-2; Src; eEF-2K; integrin; pancreatic ductal adenocarcinoma; rottlerin; tissue transglutaminase; uPAR

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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Transglutaminases / Integrin beta1 / Elongation Factor 2 Kinase / Receptors, Urokinase Plasminogen Activator Type of study: Prognostic_studies Limits: Humans Language: En Year: 2014 Type: Article

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