Chiral counteranion strategy for asymmetric oxidative C(sp³)-H/C(sp³)-H coupling: enantioselective α-allylation of aldehydes with terminal alkenes.
Angew Chem Int Ed Engl
; 53(45): 12218-21, 2014 Nov 03.
Article
in En
| MEDLINE
| ID: mdl-25219378
The first enantioselective α-allylation of aldehydes with terminal alkenes has been realized by combining asymmetric counteranion catalysis and palladium-catalyzed allylic C-H activation. This method can tolerate a wide scope of α-branched aromatic aldehydes and terminal alkenes, thus affording allylation products in high yields and with good to excellent levels of enantioselectivity. Importantly, the findings suggest a new strategy for the future creation of enantioselective C-H/C-H coupling reactions.
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En
Year:
2014
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Article