Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure.

Marelli, Udaya Kiran; Frank, Andreas O; Wahl, Bernhard; La Pietra, Valeria; Novellino, Ettore; Marinelli, Luciana; Herdtweck, Eberhardt; Groll, Michael; Kessler, Horst

Marelli, Udaya Kiran; Frank, Andreas O; Wahl, Bernhard; La Pietra, Valeria; Novellino, Ettore; Marinelli, Luciana; Herdtweck, Eberhardt; Groll, Michael; Kessler, Horst.

Affiliation

Marelli UK; Institute for Advanced Study (IAS) and Center for Integrated Protein Science (CIPSM), Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching (Germany).

Chemistry ; 20(44): 14201-6, 2014 Oct 27.

Article in En | MEDLINE | ID: mdl-25251673

Subject(s)

Integrin alphaVbeta3/chemistry; Snake Venoms/chemistry; Crystallography, X-Ray; Drug Design; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Solutions

Key words

Cilengitide; NMR spectroscopy; X-ray crystallography; conformational analysis; peptides

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