Your browser doesn't support javascript.
loading
Both aerobic exercise and cognitive-behavioral therapy reduce chronic fatigue in FSHD: an RCT.
Voet, Nicoline; Bleijenberg, Gijs; Hendriks, Jan; de Groot, Imelda; Padberg, George; van Engelen, Baziel; Geurts, Alexander.
Affiliation
  • Voet N; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands. Nicole.Voet@RadboudUMC.nl.
  • Bleijenberg G; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Hendriks J; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
  • de Groot I; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Padberg G; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Engelen B; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Geurts A; From the Departments of Rehabilitation (N.V., I.d.G., A.G.) and Neurology (G.P., B.v.E.), Donders Center for Neuroscience, Expert Center for Chronic Fatigue (G.B.), and Department for Health Evidence (J.H.), Radboud University Medical Center, Nijmegen, the Netherlands.
Neurology ; 83(21): 1914-22, 2014 Nov 18.
Article in En | MEDLINE | ID: mdl-25339206
ABSTRACT

OBJECTIVE:

To investigate the effect of aerobic exercise training (AET) and cognitive-behavioral therapy (CBT) on chronic fatigue in patients with facioscapulohumeral muscular dystrophy (FSHD).

METHODS:

We performed a multicenter, assessor-blinded, randomized clinical trial (RCT). Fifty-seven patients with FSHD type 1 with severe chronic fatigue were randomly allocated to AET, CBT, or usual care (UC). Outcomes were assessed before treatment, following 16 weeks of intervention, and after a 12-week follow-up. A linear mixed model for repeated measurements was used to study the estimated group differences.

RESULTS:

Following treatment, both the AET (28 participants) and CBT (25 participants) intervention groups had less fatigue relative to the UC group (24 participants), with a difference of -9.1 for AET (95% confidence interval [CI] -12.4 to -5.8) and -13.3 for CBT (95% CI -16.5 to -10.2). These beneficial effects lasted through follow-up, with a difference of -8.2 for AET (95% CI -12.4 to -5.8) and -10.2 for CBT (95% CI -14.0 to -6.3). The patients who received CBT had an increase in registered and experienced physical activity, sleep quality, and social participation. The patients who received AET had an increase in registered physical activity only. The increase in registered physical activity in both groups and the improvement in social participation following CBT were still present at follow-up.

CONCLUSIONS:

This RCT shows that AET and CBT can ameliorate chronic fatigue in patients with FSHD. CLASSIFICATION OF EVIDENCE This study provides Class III evidence that, in patients with FSHD type 1 and severe chronic fatigue, AET or CBT reduces the severity of chronic fatigue.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Exercise / Cognitive Behavioral Therapy / Muscular Dystrophy, Facioscapulohumeral / Exercise Therapy / Fatigue Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2014 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Exercise / Cognitive Behavioral Therapy / Muscular Dystrophy, Facioscapulohumeral / Exercise Therapy / Fatigue Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2014 Type: Article