Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols.

Cohen, L H; van Miert, E; Griffioen, M

Cohen, L H; van Miert, E; Griffioen, M.

Affiliation

Cohen LH; Gaubius Institute TNO, Leiden, The Netherlands.

Biochim Biophys Acta ; 1002(1): 69-73, 1989 Mar 14.

Article in En | MEDLINE | ID: mdl-2538145

Subject(s)

Carcinoma, Hepatocellular/enzymology; Farnesyl-Diphosphate Farnesyltransferase/metabolism; Intramolecular Transferases; Liver Neoplasms/enzymology; Mevalonic Acid/pharmacology; Oxidoreductases/metabolism; Sterols/metabolism; Androstenes/pharmacology; Cholesterol/biosynthesis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isomerases/antagonists & inhibitors; Lipoproteins, HDL/pharmacology; Lipoproteins, LDL/pharmacology; Lovastatin/analogs & derivatives; Lovastatin/pharmacology; Tumor Cells, Cultured

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PubMed Links

Database: MEDLINE Main subject: Oxidoreductases / Farnesyl-Diphosphate Farnesyltransferase / Sterols / Carcinoma, Hepatocellular / Intramolecular Transferases / Liver Neoplasms / Mevalonic Acid Limits: Humans Language: En Year: 1989 Type: Article

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