In vitro metabolism of an estrogen-related receptor Î³ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s.

Joo, Jeongmin; Wu, Zhexue; Lee, Boram; Shon, Jong Cheol; Lee, Taeho; Lee, In-Kyu; Sim, Taebo; Kim, Kyung-Hee; Kim, Nam Doo; Kim, Seong Heon; Liu, Kwang-Hyeon

Joo, Jeongmin; Wu, Zhexue; Lee, Boram; Shon, Jong Cheol; Lee, Taeho; Lee, In-Kyu; Sim, Taebo; Kim, Kyung-Hee; Kim, Nam Doo; Kim, Seong Heon; Liu, Kwang-Hyeon.

Affiliation

Joo J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701, Korea.

Biopharm Drug Dispos ; 36(3): 163-73, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25451157

Subject(s)

Estrogens/pharmacology; Hypoglycemic Agents/pharmacology; Microsomes, Liver/metabolism; Tamoxifen/analogs & derivatives; Cytochrome P-450 Enzyme Inhibitors/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Humans; Receptors, Estrogen/metabolism; Recombinant Proteins/metabolism; Tamoxifen/pharmacology

Key words

GSK5182; cytochrome P450; flavin-containing monooxygenase; microsomes; oxidation

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Full text: 1 Database: MEDLINE Main subject: Tamoxifen / Microsomes, Liver / Estrogens / Hypoglycemic Agents Limits: Humans Language: En Year: 2015 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Tamoxifen / Microsomes, Liver / Estrogens / Hypoglycemic Agents Limits: Humans Language: En Year: 2015 Type: Article