Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants.

Ghosh, Soma; Bhunia, Anil K; Paun, Bogdan C; Gilbert, Samuel F; Dhru, Urmil; Patel, Kalpesh; Kern, Scott E

Ghosh, Soma; Bhunia, Anil K; Paun, Bogdan C; Gilbert, Samuel F; Dhru, Urmil; Patel, Kalpesh; Kern, Scott E.

Affiliation

Ghosh S; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, 21287.

Hum Mutat ; 36(2): 260-9, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25451944

Subject(s)

BRCA2 Protein/genetics; Molecular Sequence Annotation; Amino Acid Substitution; Cell Line; Databases, Genetic; Gene Library; Genetic Association Studies; Genetic Predisposition to Disease; Hemizygote; Homologous Recombination; Humans; Mitosis; Rad51 Recombinase/genetics

Key words

BRCA2; homologous recombination; hypomorphs; shotgun library

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Full text: 1 Database: MEDLINE Main subject: BRCA2 Protein / Molecular Sequence Annotation Limits: Humans Language: En Year: 2015 Type: Article

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Full text: 1 Database: MEDLINE Main subject: BRCA2 Protein / Molecular Sequence Annotation Limits: Humans Language: En Year: 2015 Type: Article