DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure.

Koibuchi, Nobutaka; Hasegawa, Yu; Katayama, Tetsuji; Toyama, Kensuke; Uekawa, Ken; Sueta, Daisuke; Kusaka, Hiroaki; Ma, MingJie; Nakagawa, Takashi; Lin, Bowen; Kim-Mitsuyama, Shokei

Koibuchi, Nobutaka; Hasegawa, Yu; Katayama, Tetsuji; Toyama, Kensuke; Uekawa, Ken; Sueta, Daisuke; Kusaka, Hiroaki; Ma, MingJie; Nakagawa, Takashi; Lin, Bowen; Kim-Mitsuyama, Shokei.

Affiliation

Kim-Mitsuyama S; Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan. mitsuyam@gpo.kumamoto-u.ac.jp.

Cardiovasc Diabetol ; 13: 157, 2014 Nov 29.

Article in En | MEDLINE | ID: mdl-25471116

Subject(s)

Blood Glucose/drug effects; Blood Pressure/drug effects; Cardiovascular Diseases/drug therapy; Dipeptidyl-Peptidase IV Inhibitors/pharmacology; Purines/pharmacology; Quinazolines/pharmacology; Sodium Chloride, Dietary/pharmacology; Animals; Blood Pressure Determination/methods; Cardiovascular Diseases/complications; Disease Models, Animal; Heart/drug effects; Hypertension/drug therapy; Hypertension/physiopathology; Linagliptin; Male; Rats; Rats, Inbred Dahl

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Full text: 1 Database: MEDLINE Main subject: Purines / Quinazolines / Blood Glucose / Blood Pressure / Cardiovascular Diseases / Sodium Chloride, Dietary / Dipeptidyl-Peptidase IV Inhibitors Type of study: Diagnostic_studies Limits: Animals Language: En Year: 2014 Type: Article

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