Extramedullary relapse in RARA rearrangement-negative acute promyelocytic leukemia successfully treated in combination with chemotherapy, local radiotherapy, and cord blood transplantation.
J Pediatr Hematol Oncol
; 37(4): e234-7, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25493455
ABSTRACT
RARA rearrangement-negative acute promyelocytic leukemia (APL) is uncommon, and its extramedullary relapse is extremely rare. We report a 5-year-old girl with RARA rearrangement-negative APL, which recurred solely at the external auditory canal and mastoid air cells. She was successfully treated with chemotherapy, local radiotherapy, and unrelated cord blood transplantation. She has maintained complete remission for 24 months after transplantation. The clinical features and our therapeutic strategy in this patient will provide valuable information for extramedullary relapse of RARA rearrangement-negative APL.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Rearrangement
/
Leukemia, Promyelocytic, Acute
/
Receptors, Retinoic Acid
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Cord Blood Stem Cell Transplantation
Limits:
Female
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Humans
/
Infant
Language:
En
Year:
2015
Type:
Article