Phenytoin induced toxic epidermal necrolysis.
J Coll Physicians Surg Pak
; 24 Suppl 3: S267-9, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25518798
ABSTRACT
Toxic Epidermal Necrolysis (TEN) which is characterized by the detachment of the epidermis from the dermis is a rare (1.89/1.000.000 annually) and potentially life-threatening condition. The overall mortality is 20 - 30%. TEN is characterized by sudden apoptosis of keratinocytes leading to mucous membrane erosions and epidermal detachment; detachment of less than 10% of the total body surface area defines Stevens-Johnson Syndrome (SJS); when greater than 30%, it defines TEN, while intermediate cases are called SJS/TEN overlap. Many drugs, including prednisolone, cyclosporin, and intravenous immunoglobulin (IVIG), have been used in an attempt to halt the disease process. The use of phenytoin as a prophylactic anticonvulsant after brain surgery, particularly for brain tumors, is a common practice, regardless of whether the patient has a previous history of convulsions. This report described a case of haemorrhagic stroke where phenytoin use induced TEN.
Full text:
1
Database:
MEDLINE
Main subject:
Phenytoin
/
Seizures
/
Carbamazepine
/
Stevens-Johnson Syndrome
/
Drug Hypersensitivity
/
Anticonvulsants
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Year:
2014
Type:
Article