Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.
ACS Med Chem Lett
; 6(1): 58-62, 2015 Jan 08.
Article
in En
| MEDLINE
| ID: mdl-25589931
ABSTRACT
Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure-activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K i values. The potent inhibitors demonstrated sub-µM activities in both functional and mechanism-based cellular assays and also possessed desirable pharmacokinetic profiles. The lead molecule, 31, showed oral efficacy in potentiating the antiproliferative activity of irinotecan, a cytotoxic agent, in a NCI-H1299 mouse xenograft model.
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Database:
MEDLINE
Language:
En
Year:
2015
Type:
Article