ABSTRACT
OBJECTIVE:
The aim of this study is to compare the each clinical manifestation related with its
mean survival time of Krukenberg
tumors (KTs) of gastric origin versus with that of colorectal origin.
METHODS:
A total of 156 consecutive
patients diagnosed with KTs of the
ovary who underwent surgical
treatment at a single institution between 2001 and 2010 were retrospectively evaluated. Each clinical manifestation related with its
mean survival time compared two different groups.
Survival analyses and comparisons were performed using the Kaplan-Meier
method.
RESULTS:
Among the 156
patients with KT, 111
patients with KTs of gastric origin and 45
patients with KTs of colorectal origin were identified. For all
patients with KTs, median
survival time was 22.7 months. Each
mean survival time among all
patients with KTs of gastric origin and colorectal origin was 19.2 months and 27.3 months. The results showed that
mean survival time of postmenopausal
patients was 19.0 months compared with 32.5 months for premenopausal
patients (P=0.015). Among all
patients,
mean survival time of those with metachronous
cancer was longer than those with synchronous
cancer (P=0.001). In all cases, especially when only one
ovary was invaded, the
mean survival time was relatively higher (P=0.001).
CONCLUSION:
Patients with KTs of colorectal origin had a better
prognosis than those of gastric origin. In all cases of KT, the
mean survival time was significantly longer in postmenoposal
patients, metachronous
disease and unilateral ovarian involvement. Notably, synchronous,
ascites positive, and
ovary only
metastasis showed more longer
mean survival time in the KTs of colorectal origin than KTs of gastric origin.