Interaction of fenoterol stereoisomers with ß2-adrenoceptor-G s&#945; fusion proteins: antagonist and agonist competition binding.

Reinartz, Michael T; Kälble, Solveig; Wainer, Irving W; Seifert, Roland

Interaction of fenoterol stereoisomers with ß2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding.

Reinartz, Michael T; Kälble, Solveig; Wainer, Irving W; Seifert, Roland.

Affiliation

Reinartz MT; Institute for Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Naunyn Schmiedebergs Arch Pharmacol ; 388(5): 517-24, 2015 May.

Article in En | MEDLINE | ID: mdl-25637582

Subject(s)

Adrenergic beta-2 Receptor Agonists/pharmacology; Adrenergic beta-2 Receptor Antagonists/pharmacology; Fenoterol/pharmacology; GTP-Binding Protein alpha Subunits, Gs/metabolism; Receptors, Adrenergic, beta-2/metabolism; Recombinant Fusion Proteins/metabolism; Adrenergic beta-2 Receptor Agonists/chemistry; Adrenergic beta-2 Receptor Antagonists/chemistry; Animals; Baculoviridae/genetics; Binding, Competitive; Fenoterol/analogs & derivatives; GTP-Binding Protein alpha Subunits, Gs/genetics; Ligands; Molecular Structure; Receptors, Adrenergic, beta-2/genetics; Recombinant Fusion Proteins/genetics; Sf9 Cells; Spodoptera; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Recombinant Fusion Proteins / Receptors, Adrenergic, beta-2 / GTP-Binding Protein alpha Subunits, Gs / Fenoterol / Adrenergic beta-2 Receptor Agonists / Adrenergic beta-2 Receptor Antagonists Limits: Animals Language: En Year: 2015 Type: Article

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