Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
Nat Neurosci
; 18(3): 373-5, 2015 Mar.
Article
in En
| MEDLINE
| ID: mdl-25643294
ABSTRACT
To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.
Full text:
1
Database:
MEDLINE
Main subject:
Suprachiasmatic Nucleus
/
Action Potentials
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Circadian Rhythm
/
Motor Activity
/
Neurons
Limits:
Animals
Language:
En
Year:
2015
Type:
Article