Bis-3-chloropiperidines containing bridging lysine linkers: Influence of side chain structure on DNA alkylating activity.

Zuravka, Ivonne; Roesmann, Rolf; Sosic, Alice; Göttlich, Richard; Gatto, Barbara

Zuravka, Ivonne; Roesmann, Rolf; Sosic, Alice; Göttlich, Richard; Gatto, Barbara.

Affiliation

Zuravka I; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany; Dipartimento di Scienze del Farmaco, Università di Padova, via Marzolo 5, 35131 Padova, Italy.
Roesmann R; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany.
Sosic A; Dipartimento di Scienze del Farmaco, Università di Padova, via Marzolo 5, 35131 Padova, Italy.
Göttlich R; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany. Electronic address: richard.goettlich@uni-giessen.de.
Gatto B; Dipartimento di Scienze del Farmaco, Università di Padova, via Marzolo 5, 35131 Padova, Italy. Electronic address: barbara.gatto@unipd.it.

Bioorg Med Chem ; 23(6): 1241-50, 2015 Mar 15.

Article in En | MEDLINE | ID: mdl-25693786

Subject(s)

DNA/chemistry; DNA/drug effects; Lysine/chemistry; Piperidines/chemistry; Piperidines/pharmacology; Alkylation/drug effects; DNA Cleavage; Lysine/pharmacology; Molecular Structure; Piperidines/chemical synthesis; Plasmids

Key words

Alkylating agents; Aziridinium ion; Bis-3-chloropiperidines; DNA cleavage; Nitrogen mustards

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