Hepatolenticular Degeneration/metabolism; Laser Therapy; Mass Spectrometry/methods; Metals/metabolism; Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Adolescent; Animals; Base Sequence; Blotting, Western; Cation Transport Proteins/genetics; Cation Transport Proteins/metabolism; Copper/metabolism; Copper-Transporting ATPases; DNA Mutational Analysis; Diagnostic Imaging/methods; Disease Models, Animal; Female; Hepatolenticular Degeneration/diagnosis; Hepatolenticular Degeneration/genetics; Humans; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Iron/metabolism; Liver/metabolism; Liver/pathology; Male; Mice, 129 Strain; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1/genetics; Tissue Inhibitor of Metalloproteinase-1/metabolism; Young Adult; Zinc/metabolism

Wilson's disease; laser ablation inductively coupled plasma mass spectrometry; liver; metal bio-imaging; trace metals