RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

Stefanini, Lucia; Paul, David S; Robledo, Raymond F; Chan, E Ricky; Getz, Todd M; Campbell, Robert A; Kechele, Daniel O; Casari, Caterina; Piatt, Raymond; Caron, Kathleen M; Mackman, Nigel; Weyrich, Andrew S; Parrott, Matthew C; Boulaftali, Yacine; Adams, Mark D; Peters, Luanne L; Bergmeier, Wolfgang

Stefanini, Lucia; Paul, David S; Robledo, Raymond F; Chan, E Ricky; Getz, Todd M; Campbell, Robert A; Kechele, Daniel O; Casari, Caterina; Piatt, Raymond; Caron, Kathleen M; Mackman, Nigel; Weyrich, Andrew S; Parrott, Matthew C; Boulaftali, Yacine; Adams, Mark D; Peters, Luanne L; Bergmeier, Wolfgang.

J Clin Invest ; 125(4): 1419-32, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25705885

Subject(s)

GTPase-Activating Proteins/physiology; Platelet Activation/physiology; rap1 GTP-Binding Proteins/antagonists & inhibitors; Animals; Cellular Senescence; Clopidogrel; GTPase-Activating Proteins/genetics; Guanine Nucleotide Exchange Factors/deficiency; Hemostasis; Lymphopenia/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation/drug effects; Platelet Activation/genetics; Platelet Aggregation Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/physiology; Receptors, Purinergic P2Y12/physiology; Saphenous Vein/injuries; Splenectomy; Thrombocytopenia/genetics; Thrombocytopenia/surgery; Thrombopoiesis; Ticlopidine/analogs & derivatives; Ticlopidine/pharmacology; rap1 GTP-Binding Proteins/physiology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Platelet Activation / Rap1 GTP-Binding Proteins / GTPase-Activating Proteins Limits: Animals Language: En Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google