Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.

Warth, Sebastian C; Hoefig, Kai P; Hiekel, Anian; Schallenberg, Sonja; Jovanovic, Ksenija; Klein, Ludger; Kretschmer, Karsten; Ansel, K Mark; Heissmeyer, Vigo

Warth, Sebastian C; Hoefig, Kai P; Hiekel, Anian; Schallenberg, Sonja; Jovanovic, Ksenija; Klein, Ludger; Kretschmer, Karsten; Ansel, K Mark; Heissmeyer, Vigo.

Affiliation

Warth SC; Helmholtz Zentrum München, Research Unit Molecular Immune Regulation, Institute of Molecular Immunology, Munich, Germany.
Hoefig KP; Helmholtz Zentrum München, Research Unit Molecular Immune Regulation, Institute of Molecular Immunology, Munich, Germany.
Hiekel A; Helmholtz Zentrum München, Research Unit Molecular Immune Regulation, Institute of Molecular Immunology, Munich, Germany.
Schallenberg S; Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
Jovanovic K; Institute for Immunology, University of Munich, Munich, Germany.
Klein L; Institute for Immunology, University of Munich, Munich, Germany.
Kretschmer K; Molecular and Cellular Immunology/Immune Regulation, DFG-Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
Ansel KM; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Heissmeyer V; Helmholtz Zentrum München, Research Unit Molecular Immune Regulation, Institute of Molecular Immunology, Munich, Germany Institute for Immunology, University of Munich, Munich, Germany vigo.heissmeyer@med.uni-muenchen.de.

EMBO J ; 34(9): 1195-213, 2015 May 05.

Article in En | MEDLINE | ID: mdl-25712478

Subject(s)

MicroRNAs/genetics; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/physiology; TOR Serine-Threonine Kinases/genetics; 3' Untranslated Regions; Animals; Base Sequence; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/physiology; Cell Differentiation/genetics; Cells, Cultured; DEAD-box RNA Helicases/genetics; DEAD-box RNA Helicases/metabolism; Gene Expression Regulation/drug effects; Gene Regulatory Networks; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Ribonuclease III/genetics; Ribonuclease III/metabolism; T-Lymphocytes, Regulatory/drug effects; TOR Serine-Threonine Kinases/metabolism; Tretinoin/pharmacology

Key words

Treg cells; Tcell differentiation; miRNA function

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / MicroRNAs / TOR Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Animals Language: En Year: 2015 Type: Article

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