The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.

Mehra, Smriti; Foreman, Taylor W; Didier, Peter J; Ahsan, Muhammad H; Hudock, Teresa A; Kissee, Ryan; Golden, Nadia A; Gautam, Uma S; Johnson, Ann-Marie; Alvarez, Xavier; Russell-Lodrigue, Kasi E; Doyle, Lara A; Roy, Chad J; Niu, Tianhua; Blanchard, James L; Khader, Shabaana A; Lackner, Andrew A; Sherman, David R; Kaushal, Deepak

Mehra, Smriti; Foreman, Taylor W; Didier, Peter J; Ahsan, Muhammad H; Hudock, Teresa A; Kissee, Ryan; Golden, Nadia A; Gautam, Uma S; Johnson, Ann-Marie; Alvarez, Xavier; Russell-Lodrigue, Kasi E; Doyle, Lara A; Roy, Chad J; Niu, Tianhua; Blanchard, James L; Khader, Shabaana A; Lackner, Andrew A; Sherman, David R; Kaushal, Deepak.

Affiliation

Mehra S; 1 Division of Microbiology.

Am J Respir Crit Care Med ; 191(10): 1185-96, 2015 May 15.

Article in En | MEDLINE | ID: mdl-25730547

Subject(s)

Bacterial Proteins/genetics; Hypoxia/metabolism; Mycobacterium tuberculosis/genetics; Protein Kinases/genetics; Regulon/genetics; Tuberculosis/genetics; Animals; Bacterial Proteins/immunology; DNA-Binding Proteins; Disease Models, Animal; Macaca mulatta; Mycobacterium tuberculosis/immunology; Protein Kinases/immunology; Regulon/immunology; T-Lymphocytes/immunology; Tuberculosis/immunology; Tuberculosis/prevention & control

Key words

T-cell response; hypoxia; modulation; nonhuman primate; tuberculosis

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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / Bacterial Proteins / Tuberculosis / Regulon / Hypoxia / Mycobacterium tuberculosis Limits: Animals Language: En Year: 2015 Type: Article

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