Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody.

Reilly, Edward B; Phillips, Andrew C; Buchanan, Fritz G; Kingsbury, Gillian; Zhang, Yumin; Meulbroek, Jonathan A; Cole, Todd B; DeVries, Peter J; Falls, Hugh D; Beam, Christine; Gu, Jinming; Digiammarino, Enrico L; Palma, Joann P; Donawho, Cherrie K; Goodwin, Neal C; Scott, Andrew M

Reilly, Edward B; Phillips, Andrew C; Buchanan, Fritz G; Kingsbury, Gillian; Zhang, Yumin; Meulbroek, Jonathan A; Cole, Todd B; DeVries, Peter J; Falls, Hugh D; Beam, Christine; Gu, Jinming; Digiammarino, Enrico L; Palma, Joann P; Donawho, Cherrie K; Goodwin, Neal C; Scott, Andrew M.

Affiliation

Reilly EB; AbbVie, Cancer Discovery, North Chicago, Illinois. ed.reilly@abbvie.com.
Phillips AC; AbbVie, Cancer Discovery, North Chicago, Illinois.
Buchanan FG; AbbVie, Cancer Discovery, North Chicago, Illinois.
Kingsbury G; AbbVie Bioresearch Center, Worcester, Massachusetts.
Zhang Y; AbbVie, Cancer Discovery, North Chicago, Illinois.
Meulbroek JA; AbbVie, Cancer Discovery, North Chicago, Illinois.
Cole TB; AbbVie, Cancer Discovery, North Chicago, Illinois.
DeVries PJ; AbbVie, Cancer Discovery, North Chicago, Illinois.
Falls HD; AbbVie, Cancer Discovery, North Chicago, Illinois.
Beam C; AbbVie Bioresearch Center, Worcester, Massachusetts.
Gu J; AbbVie Bioresearch Center, Worcester, Massachusetts.
Digiammarino EL; AbbVie, Cancer Discovery, North Chicago, Illinois.
Palma JP; AbbVie, Cancer Discovery, North Chicago, Illinois.
Donawho CK; AbbVie, Cancer Discovery, North Chicago, Illinois.
Goodwin NC; The Jackson Laboratory, Sacramento, California.
Scott AM; Ludwig Institute for Cancer Research, Olivia Newton-John Cancer Research Institute, and La Trobe University, Melbourne, Victoria, Australia.

Mol Cancer Ther ; 14(5): 1141-51, 2015 May.

Article in En | MEDLINE | ID: mdl-25731184

Subject(s)

Antibodies, Monoclonal, Humanized/administration & dosage; Antineoplastic Agents/administration & dosage; Cetuximab/administration & dosage; ErbB Receptors/immunology; ErbB Receptors/metabolism; Neoplasms/drug therapy; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized/pharmacology; Antineoplastic Agents/pharmacology; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/pathology; Cell Line, Tumor; Cetuximab/pharmacology; Glioblastoma/drug therapy; Glioblastoma/metabolism; Glioblastoma/pathology; Head and Neck Neoplasms/drug therapy; Head and Neck Neoplasms/metabolism; Head and Neck Neoplasms/pathology; Humans; Mice; Neoplasms/metabolism; Neoplasms/pathology; Protein Binding; Standard of Care; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized / ErbB Receptors / Cetuximab / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2015 Type: Article

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