6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human &#945;7 nicotinic acetylcholine receptor.

Kasheverov, Igor E; Shelukhina, Irina V; Kudryavtsev, Denis S; Makarieva, Tatyana N; Spirova, Ekaterina N; Guzii, Alla G; Stonik, Valentin A; Tsetlin, Victor I

6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.

Kasheverov, Igor E; Shelukhina, Irina V; Kudryavtsev, Denis S; Makarieva, Tatyana N; Spirova, Ekaterina N; Guzii, Alla G; Stonik, Valentin A; Tsetlin, Victor I.

Affiliation

Kasheverov IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, Moscow 117997, Russia. iekash@mx.ibch.ru.
Shelukhina IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, Moscow 117997, Russia. ner-neri@mail.ru.
Kudryavtsev DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, Moscow 117997, Russia. kudryavtsev@ibch.ru.
Makarieva TN; Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia. makarieva@piboc.dvo.ru.
Spirova EN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, Moscow 117997, Russia. katya_spirova@mail.ru.
Guzii AG; Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia. gagry@rambler.ru.
Stonik VA; Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia. stonik@piboc.dvo.ru.
Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, Moscow 117997, Russia. vits@mx.ibch.ru.

Mar Drugs ; 13(3): 1255-66, 2015 Mar 12.

Article in En | MEDLINE | ID: mdl-25775422

Subject(s)

Hermissenda/metabolism; Nicotinic Agonists/pharmacology; Tryptophan/analogs & derivatives; alpha7 Nicotinic Acetylcholine Receptor/agonists; Animals; Binding, Competitive; Chickens; Humans; Inhibitory Concentration 50; Molecular Weight; Nicotinic Agonists/administration & dosage; Nicotinic Agonists/isolation & purification; Oocytes; Patch-Clamp Techniques; Rats; Receptors, Nicotinic/drug effects; Receptors, Nicotinic/metabolism; Species Specificity; Torpedo; Tryptophan/administration & dosage; Tryptophan/isolation & purification; Tryptophan/pharmacology; Xenopus laevis

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Full text: 1 Database: MEDLINE Main subject: Tryptophan / Nicotinic Agonists / Hermissenda / Alpha7 Nicotinic Acetylcholine Receptor Limits: Animals / Humans Language: En Year: 2015 Type: Article

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