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REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial.
King, A; Barton, D; Beard, H A; Than, N; Moore, J; Corbett, C; Thomas, J; Guo, K; Guha, I; Hollyman, D; Stocken, D; Yap, C; Fox, R; Forbes, S J; Newsome, P N.
Affiliation
  • King A; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
  • Barton D; NIHR Liver BRU Clinical trials group (EDD), CRUK clinical trials unit, University of Birmingham, Birmingham, UK.
  • Beard HA; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK Cellular and Molecular Therapies, NHS Blood and Transplant, Birmingham, UK.
  • Than N; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK.
  • Moore J; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Corbett C; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK.
  • Thomas J; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Guo K; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK.
  • Guha I; National Institute for Health Research Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
  • Hollyman D; Cellular and Molecular Therapies, NHS Blood and Transplant, Birmingham, UK.
  • Stocken D; Newcastle Clinical Trial Unit, Institute of Health and Society, Newcastle University, Newcastle, UK.
  • Yap C; NIHR Liver BRU Clinical trials group (EDD), CRUK clinical trials unit, University of Birmingham, Birmingham, UK.
  • Fox R; NIHR Liver BRU Clinical trials group (EDD), CRUK clinical trials unit, University of Birmingham, Birmingham, UK.
  • Forbes SJ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Newsome PN; NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, Birmingham, UK Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
BMJ Open ; 5(3): e007700, 2015 Mar 20.
Article in En | MEDLINE | ID: mdl-25795699

Full text: 1 Database: MEDLINE Main subject: Adjuvants, Immunologic / Granulocyte Colony-Stimulating Factor / Hematopoietic Stem Cell Transplantation / Cell- and Tissue-Based Therapy / Liver Cirrhosis Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Language: En Year: 2015 Type: Article

Full text: 1 Database: MEDLINE Main subject: Adjuvants, Immunologic / Granulocyte Colony-Stimulating Factor / Hematopoietic Stem Cell Transplantation / Cell- and Tissue-Based Therapy / Liver Cirrhosis Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Language: En Year: 2015 Type: Article