Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study.

Dowling, Ryan J O; Niraula, Saroj; Chang, Martin C; Done, Susan J; Ennis, Marguerite; McCready, David R; Leong, Wey L; Escallon, Jaime M; Reedijk, Michael; Goodwin, Pamela J; Stambolic, Vuk

Dowling, Ryan J O; Niraula, Saroj; Chang, Martin C; Done, Susan J; Ennis, Marguerite; McCready, David R; Leong, Wey L; Escallon, Jaime M; Reedijk, Michael; Goodwin, Pamela J; Stambolic, Vuk.

Breast Cancer Res ; 17: 32, 2015 Mar 03.

Article in En | MEDLINE | ID: mdl-25849721

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/metabolism; Metformin/pharmacology; Receptor, Insulin/metabolism; Signal Transduction/drug effects; Adult; Aged; Antineoplastic Agents/therapeutic use; Biomarkers/metabolism; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Female; Humans; Metformin/therapeutic use; Middle Aged; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Receptor, Insulin / Signal Transduction / Metformin / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Year: 2015 Type: Article

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