Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations.

Sahbaz, Yasemin; Williams, Hywel D; Nguyen, Tri-Hung; Saunders, Jessica; Ford, Leigh; Charman, Susan A; Scammells, Peter J; Porter, Christopher J H

Sahbaz, Yasemin; Williams, Hywel D; Nguyen, Tri-Hung; Saunders, Jessica; Ford, Leigh; Charman, Susan A; Scammells, Peter J; Porter, Christopher J H.

Affiliation

Porter CJ; â¥ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Mol Pharm ; 12(6): 1980-91, 2015 Jun 01.

Article in En | MEDLINE | ID: mdl-25905624

Subject(s)

Ionic Liquids/chemistry; Animals; Chemistry, Pharmaceutical/methods; Cinnarizine/chemistry; Drug Delivery Systems/methods; Itraconazole/chemistry; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Solubility

Key words

cinnarizine; drug absorption; ionic liquid; itraconazole; lipid-based formulation; poorly water-soluble drug

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