Effect of Levosimendan on Diastolic Function in Patients Undergoing Coronary Artery Bypass Grafting: A Comparative Study.
J Cardiovasc Pharmacol
; 66(2): 141-7, 2015 Aug.
Article
in En
| MEDLINE
| ID: mdl-25919118
ABSTRACT
PURPOSE:
To compare the efficacy of levosimendan with nitroglycerin in patients with isolated diastolic dysfunction undergoing coronary artery bypass grafting. PROCEDURE Thirty patients with isolated diastolic dysfunction undergoing on-pump coronary artery bypass grafting were randomized into 2 groups receiving levosimendan or nitroglycerin infusion. The infusion was started before sternotomy and continued in the postoperative period. Perioperatively, diastolic function was serially evaluated at 3 different time points using echocardiography. N-terminal fragment of pro-B-natriuretic peptide (NT-proBNP) levels were measured in both the groups.RESULTS:
There was a significant improvement in diastolic function as measured by isovolumic relaxation time (P = 0.0001, P = 0.001) and deceleration time (P = 0.0001, P = 0.0001) in the levosimendan group from the baseline in patients with impaired relaxation. Similarly, tissue Doppler imaging also revealed an improvement from the baseline in patients with a pseudonormal pattern (P = 0.018, P = 0.001). Furthermore, there was a significant improvement in the above parameters when compared with the nitroglycerin group. The NT-proBNP levels also demonstrated a similar pattern between the 2 groups (P = 0.03, P = 0.02) when levosimendan was compared with nitroglycerin in patients with a pseudonormal pattern on echocardiography.CONCLUSIONS:
Levosimendan is superior to nitroglycerin in improving diastolic function irrespective of coronary revascularization.
Full text:
1
Database:
MEDLINE
Main subject:
Pyridazines
/
Vasodilator Agents
/
Blood Pressure
/
Coronary Artery Disease
/
Coronary Artery Bypass
/
Hydrazones
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Year:
2015
Type:
Article