Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance.
Int J Tuberc Lung Dis
; 19(6): 679-84, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25946359
ABSTRACT
BACKGROUND:
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.OBJECTIVE:
To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).DESIGN:
Isolates from two major urban centres--Paris (101 strains) and Shanghai (171 strains)--were investigated for the association of pncA mutations with resistance to drugs other than PZA.RESULTS:
The proportion of pncA mutations found in INH-monoresistant strains was not increased.CONCLUSION:
pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
Full text:
1
Database:
MEDLINE
Main subject:
Pyrazinamide
/
Rifampin
/
Tuberculosis, Multidrug-Resistant
/
Fluoroquinolones
/
Drug Resistance, Multiple, Bacterial
/
Mycobacterium tuberculosis
/
Antitubercular Agents
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Humans
Country/Region as subject:
Asia
/
Europa
Language:
En
Year:
2015
Type:
Article