Dextran sulfate sodium inhibits amyloid-ß oligomer binding to cellular prion protein.

Aimi, Takahiro; Suzuki, Koichiro; Hoshino, Tatsuya; Mizushima, Tohru

Aimi, Takahiro; Suzuki, Koichiro; Hoshino, Tatsuya; Mizushima, Tohru.

Affiliation

Aimi T; Faculty of Pharmacy, Keio University, Tokyo, Japan.
Suzuki K; Faculty of Pharmacy, Keio University, Tokyo, Japan.
Hoshino T; Faculty of Pharmacy, Keio University, Tokyo, Japan.
Mizushima T; Faculty of Pharmacy, Keio University, Tokyo, Japan.

J Neurochem ; 134(4): 611-7, 2015 Aug.

Article in En | MEDLINE | ID: mdl-25963375

Subject(s)

Amyloid beta-Peptides/antagonists & inhibitors; Amyloid beta-Peptides/metabolism; Dextran Sulfate/pharmacology; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/metabolism; PrPC Proteins/antagonists & inhibitors; PrPC Proteins/metabolism; Animals; COS Cells; Chlorocebus aethiops; Humans; Male; Mice; Mice, Inbred C57BL; Protein Binding/drug effects; Protein Binding/physiology

Key words

Alzheimer's disease; amyloid beta; cellular prion protein; dextran sulfate sodium

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Full text: 1 Database: MEDLINE Main subject: Peptide Fragments / Amyloid beta-Peptides / Dextran Sulfate / PrPC Proteins Limits: Animals / Humans / Male Language: En Year: 2015 Type: Article

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